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Products CRK Protein Lysate (GST tagged) (Expressed in bacteria) (200ug)
| Presku: | APL10439 |
| Size: | 200ug |
| Weight: | 38 |
| Gene: | 1398 |
| Target: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
| Alternative names: | CRKII; p38 |
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