Reactivities: | Human, Rat |
Presku: | AAP34778 |
Size: | 100ug |
Weight: | 39kDa |
Gene: | 25620 |
Format: | Lyophilized powder |
Target: | Crem is a transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform Delta is an activator. Crem plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform Tau (activator) to CRE is increased by CREB3L4. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange. |
Alternative names: | Icer |