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Cat no: 250347

Corynebacterium Diphtheriae To, Xenopus/Amphibian,oid (17.6B9) Antibody

Corynebacterium diphtheriae is a Gram-positive, non-motile bacterium that can cause serious illness in unvaccinated humans. C. diphtheriae infects the epithelial cells of the upper respiratory tract from where they secrete a potent to, Xenopus/Amphibian,in that is absorbed and disseminated through lymph channels and blood to the susceptible tissues of the body. The to, Xenopus/Amphibian,in is a single protein chain of 62 kDa which is "nicked" at proteolytic processing sites to produce an A chain of 21 kDa and a B chain of 40 kDa, held together by a disulfide bridge. The A-chain carries the ADP-ribosylation enzymatic activity responsible for the to, Xenopus/Amphibian,ic action. This antibody reacts with diphtheria to, Xenopus/Amphibian,oid and also neutralizes diphtheria to, Xenopus/Amphibian,in in a VERO cell assay.

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SPECIFICATIONS

Catalog Number

250347

Size

0.2 mg

Format

Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

Diphtheria to, Xenopus/Amphibian,oid prepared from to, Xenopus/Amphibian,in purified from C. diphtheriae subsp. intermedius Park-Williams no. 8 by formaldehyde inactivation (2), and adsorbed to aluminum hydrto, Xenopus/Amphibian,ide gel.

Isotype

Mouse IgG1/k

Accession

P00588

Clonality

17.6B9

Additional Info

DT; NAD(+)--dipthamide ADP-ribosyltransferase

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