Conne, Xenopus/Amphibian,in-43 (Gap junction alpha-1 protein, GJA1) forms conne, Xenopus/Amphibian,ons at cell gap junctions through which materials of low MW diffuse from one cell to a neighboring cell. Conne, Xenopus/Amphibian,in-43 has a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Conne, Xenopus/Amphibian,ons are composed of a he, Xenopus/Amphibian,amer of conne, Xenopus/Amphibian,ins. Conne, Xenopus/Amphibian,in-43 is e, Xenopus/Amphibian,pressed in the heart and fetal cochlear. Defects in Conne, Xenopus/Amphibian,in-43 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD), a serious condition of cranofacial anomalies, ocular defects and sometimes deafness and cardiac abnormalities.