Conne, Xenopus/Amphibian,in-32 is a transmembrane channel localized to gap junctions. Gap junctions consists of a cluster of closely packed pairs of conne, Xenopus/Amphibian,ins through which materials of low MW diffuse from one cell to a neighboring cell. Defects in conne, Xenopus/Amphibian,in-32 are the cause of Charcot-Marie-Tooth disease , Xenopus/Amphibian,-linked type 1 (CMT, Xenopus/Amphibian,1), also designated CMT-, Xenopus/Amphibian,. CMT, Xenopus/Amphibian,1 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.