CNTFR-alpha Antibody

Ciliary neurotrophic factor receptor subunit alpha (CNTFR) is hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor comple, Xenopus/Amphibian,, which also includes LIFR and gp130. CNTFR is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor comple, Xenopus/Amphibian,. Signal transduction stimulates gene e, Xenopus/Amphibian,pression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.