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Cish (cytokine inducible SH2-containing protein) Blocking Peptide (the N terminal of Cish)(100ug)

Cish (cytokine inducible SH2-containing protein) Blocking Peptide (the N terminal of Cish)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Cish Antibody (ARP52798_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP52798
Size: 100ug
Weight: 28kDa
Gene: 12700
Format: Lyophilized powder
Target: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alternative names: AI385595; CIS1; Cis; F17; F23
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