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CILP (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase ) Blocking Peptide (the C terminal of CILP)(100ug)

CILP (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase ) Blocking Peptide (the C terminal of CILP)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-CILP Antibody (ARP64683_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP64683
Size: 100ug
Weight: 52kDa
Gene: 8483
Format: Lyophilized powder
Target: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
Alternative names: CILP-1; HsT18872
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