After binding acetylcholine, the neuronal acetylcholine receptor (CHRNA4) responds by an e, Xenopus/Amphibian,tensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in CHRNA4 are the cause of nocturnal frontal lobe epilepsy type 1 (ENFL1), also symbolized ADNFLE. ENFL1 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.