
Supplier:
Aviva Systems Biology IncorporatedChmp2b (charged multivesicular body protein 2B ) Blocking Peptide (the N terminal of Chmp2b)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum, Rat
Format
Lyophilized powder
Presku
AAP54967
Target
Chmp2b is involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Chmp2b recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Chmp2b redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery Chmp2b also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Involved in cytokinesis .
Weight
23kDa
Gene Id
363720
Alternative Names
RGD1306781
Applications
ELISA, WB
Hosts
Mouse
Applications
IHC
Hosts
Mouse
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