Home  >  Products  >  CHFR (checkpoint with forkhead and ring finger domains) Blocking Peptide (the N terminal of protein) (100ug)
CHFR (checkpoint with forkhead and ring finger domains) Blocking Peptide (the N terminal of protein) (100ug)

CHFR (checkpoint with forkhead and ring finger domains) Blocking Peptide (the N terminal of protein) (100ug)

Supplier: Aviva Systems Biology Incorporated
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
This is a synthetic peptide designed for use in combination with anti-CHFR antibody (Catalogue #: ARP43250_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP43250
Size: 100 ug
Weight: 69kDa
Gene: 55743
Format: Lyophilized powder
Target: CHFR is an E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome moves apart from each other along the periphery of the nucleus. CHFR probably promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons.
Alternative names: FLJ10796; FLJ33629; RNF116; RNF196
See Full Product Listings >