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CHD4 Human - Recombinant Human Chromodomain Helicase DNA Binding Protein 4 (5ug)

CHD4 Human - Recombinant Human Chromodomain Helicase DNA Binding Protein 4 (5ug)

Product Introduction: CHD4 is a member of a family of alleged chromodomain helicase-DNA-binding proteins. Biochemically, CHD4 is a component of the nucleosome transformation and deacetylase (NuRD) complex that takes part in transcription regulation. Autoantibodies targeting the CHD4 are a serologic feature of idiopathic inflammatory myopathies (IIM). In IIM Mi-2 antibodies are characterized by diagnostic sensitivity and specificity of approximately 4-18% and 98-100%, respectively. Moreover, anti-CHD4 antibodies are related to dermatomyositis (frequency up to 31%) and have a great positive predictive value for this type of disease subset. Anti-CHD4 are the only defined myositis-specific autoantibodies clearly focused to a nuclear target. An additional slightly outstanding feature of Mi-2 antibodies relates to their frequency in children, which is similar to that in adults.
Product Description: CHD4 is a full-length cDNA coding for the human Mi-2 beta isoform having a molecular mass of 221,298 Dalton (pH 5.8). CHD4 protein is fused to a hexa-histidine purification tag.

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SPECIFICATIONS

Size

5ug

Presku

OPPA00068

Alternative Names

Chromodomain Helicase DNA binding protein 4; Mi-2b; Mi2-BETA; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; EC 3.6.4.12; EC 3.6.1.

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