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CENTG1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2) Blocking Peptide (the middle region of CENTG1)(100ug)

CENTG1 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 2) Blocking Peptide (the middle region of CENTG1)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-CENTG1 Antibody(ARP52356_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP52356
Size: 100ug
Weight: 90kDa
Gene: 116986
Format: Lyophilized powder
Target: CENTG1 is a GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Alternative names: AGAP2; FLJ16430; GGAP2; KIAA0167; PIKE
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