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CDKN1B (Human) cDNA (1ug)

CDKN1B (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human CDKN1B is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-CDKN1B polyclonal antibody.
Presku: ANA10434
Size: 1ug
Gene: 1027
Target: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
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