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CDK8 Antibody

CDK8 Antibody

Cat no: 251215


Supplier: ABBIOTEC
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Cyclin-dependent kinase 8 (CDK8) is a component of the Mediator comple, Xenopus/Amphibian,, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation comple, Xenopus/Amphibian, with RNA polymerase II and the general transcription factors. CDK8 phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation comple, Xenopus/Amphibian,.
Catalogue number: 251215
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P49336
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CDK8.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: CDK8; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator of RNA polymerase II transcription subunit CDK8; Mediator comple, Xenopus/Amphibian, subunit CDK8; Protein kinase K35