Home  >  Products  >  Cdk4 Antibody
Cdk4 Antibody

Cdk4 Antibody

Cat no: 251727


Supplier: ABBIOTEC
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Cyclin-dependent kinase 4 (Cdk4) is the Ser/Thr-kinase component of cyclin D-CDK4 (DC) comple, Xenopus/Amphibian,es that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 by Cdk4 allows dissociation of the transcription factor E2F from the RB/E2F comple, Xenopus/Amphibian,es and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in Cdk4 are a cause of susceptibility to cutaneous malignant melanoma type 3 (CMM3). Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-e, Xenopus/Amphibian,isting benign nevus, which occurs most often in the skin but also may involve other sites.
Catalogue number: 251727
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P11802, NP_000066
Antigen: Recombinant human Cdk4 protein.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Mouse Monoclonal Antibody
Isotype: Mouse IgG2a
Clonality: IML-4
Additional info: Cell division protein kinase 4; Cyclin-dependent kinase 4; PSK-J3; CDK4