Reactivities: | Human |
Presku: | AAP64230 |
Size: | 100ug |
Weight: | 12kDa |
Gene: | 8099 |
Format: | Lyophilized powder |
Target: | The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. |
Alternative names: | DOC1; DORC1; ST19; doc-1; p12DOC-1 |