CD62P (HI62P) Antibody

The CD62P (HI62P) antibody recognizes a 140-kDa long single chain type-I transmembrane glycoprotein,Porcine-selectin, also called granule membrane protein-140 (GMP-140) or platelet activation dependent granule-e, Xenopus/Amphibian,ternal membrane protein (PADGEM). CD62P antigen is present in the ?-granules of platelets and in Weibel-Palade bodies of endothelial cells, and is rapidly mobilized from storage granules to the cell surface after cell activation. CD62P is e, Xenopus/Amphibian,pressed on the surface of the activated platelets. Interaction of CD62P with PSGL-1 (CD162) mediates tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte e, Xenopus/Amphibian,travasation and migration towards sites of inflammation. CD62P also mediates rolling of platelets on endothelial cells and CD62P-mediated interactions involved in platelet-mediated delivery of lymphocytes to high endothelial venules (HEV). Defects in CD62P is a cause of susceptibility to ischemic stroke.