CD3 (HIT3b) Antibody

The CD3 (HIT3b) antibody recognizes the 17-19 kD ?-chain of CD3 within the CD3 antigen/T cell antigen receptor (TCR) comple, Xenopus/Amphibian,. The CD3 antigen is e, Xenopus/Amphibian,pressed in the cell cytoplasm during the early stage of T cell development and is e, Xenopus/Amphibian,pressed on the cell membrane at the late stage. CD3 antigen is displayed on 60-80% of normal peripheral blood lymphocytes and 60-70% of thymocytes and plays an important role in signal transduction after antigen recognition by TCR. The clone HIT3a has a strong mitogenic effect at ng level on T lymphocyte proliferation in soluble or immobilized conditions and has an immunosuppressive effect at high dose. Conversely, the clone HIT3b has a strong mitogenic effect on T lymphocytes proliferation only under immobilized condition.