Reactivities: | Human |
Presku: | AAP59093 |
Size: | 100ug |
Weight: | 27kDa |
Gene: | 939 |
Format: | Lyophilized powder |
Target: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. |
Alternative names: | MGC20393; S152; T14; TNFRSF7; Tp55 |