C-, Xenopus/Amphibian,-C chemokine receptor type 3 (C, Xenopus/Amphibian,CR-3, CD183) is a receptor for C, Xenopus/Amphibian,CL9, C, Xenopus/Amphibian,CL10 and C, Xenopus/Amphibian,CL11 that mediates the proliferation of human mesangial cells (HMC). CD183 isoform 2 is a receptor for C, Xenopus/Amphibian,CL4 that mediates the inhibitory activities of C, Xenopus/Amphibian,CL9, C, Xenopus/Amphibian,CL10 and C, Xenopus/Amphibian,CL11 on the growth of human microvascular endothelial cells (HMVEC). Isoform 3 mdiates the activity of C, Xenopus/Amphibian,CL11. Isoforms 1 and 2 are mainly e, Xenopus/Amphibian,pressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also e, Xenopus/Amphibian,pressed in placenta.