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CD10 Monoclonal Antibody

Cat no: ABM40072

CD10 Monoclonal Antibody

MME encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). Membrane metalloendopeptidase is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. Membrane metalloendopeptidase is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. Membrane metalloendopeptidase is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of MME is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

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SPECIFICATIONS

Catalog Number

ABM40072

Size

30micro l, 100micro l, 200micro l

Applications

IF, IHC-F

Hosts

Mouse

Reactivities

Hum, Mouse, Rat

Gene Id

4311

Isotype

Mouse IgG1

Accession

P08473

Clonality

Monoclonal

Concentration

1 mg/ml

SUPPLIER INFO

Abbkine Scientific Co.Ltd.

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