Reactivities: | Human |
Presku: | AAP30901 |
Size: | 100ug |
Weight: | 21kDa |
Gene: | 865 |
Format: | Lyophilized powder |
Target: | CBFB encodes a protein that is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. |
Alternative names: | PEBP2B |