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Caspase-12

Caspase-12

Cat no: 251476

Supplier: ABBIOTEC
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Inactive caspase-12 (caspase-12) reduces cytokine release in response to bacterial lipopolysaccharide during infections. Caspase-12 reduces reduces activation of NF-kappa-B in response to TNF. Caspase-12 does not have protease activity. The most frequent caspase-12 variant has a stop codon instead of Arg-125, giving rise to a truncated protein (Csp12-S). The variant Arg-125 (Csp12-L) is rare, e, Xenopus/Amphibian,cept in some populations from sub-Saharan Africa. Csp12-L may increase the susceptibility to severy sepsis, and may also increase the mortality rate in sepsis patients.
Catalogue number: 251476
Reactivities: Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: Q6U, Xenopus/Amphibian,S9
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of mouse caspase-12.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: Caspase-12; Inactive caspase-12; CASP12; CASP-12
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