Supplier:
Aviva Systems Biology IncorporatedCASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)) Blocking Peptide (the middle region of CASP1)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum
Format
Lyophilized powder
Presku
AAP58983
Target
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.
Weight
10kDa
Gene Id
834
Alternative Names
ICE; IL1BC; P45
SUPPLIER INFO
Applications
ELISA, WB
Hosts
Mouse
Applications
IHC
Hosts
Mouse
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