Presku: | AAP40869 |
Size: | 100 ug |
Weight: | 64kDa |
Gene: | 55602 |
Format: | Lyophilized powder |
Target: | CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2. |