CaMK-II (Thr286) Antibody

CaM Kinase 2 alpha (CAMKII alpha) is a prominent Ser/Thr kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. A member of the NMDAR signaling comple, Xenopus/Amphibian, at the e, Xenopus/Amphibian,citatory synapse, it regulates NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. CAMK2a is composed of alpha, beta, gamma, and delta chains that assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. CaMK2a interacts with BAALC,Mouse,PDZ, SYN1, CAMK2N2 and SYNGAP1. Phosphorylation of Thr286 produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II.

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SPECIFICATIONS

Catalog Number

252526

Size

0.1 ml

Applications

WB

Reactivities

Hum, Mouse, Xen/Amph

Format

Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.

P Type

Rabbit Polyclonal Antibody,Porcinehosphospecific Antibody

Antigen

KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Thr286 of human CaMK-II.

Isotype

Rabbit IgG

Accession

P11275

Additional Info

CaMK2a; Calcium/calmodulin-dependent protein kinase type II alpha chain; CaM-kinase II alpha chain; CaM kinase II subunit alpha; CaMK-II subunit alpha; CaMK-II beta; Calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase II beta; Calcium/calmodulin-dependent protein kinase II(B); CaM-kinase II beta chain; CaM kinase II subunit beta; CaMK-II subunit beta; CaMKII(B); CAMK2B; CAM2; CAMKB