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C3 Complement beta-chain variant (8G4) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250286

C3 Complement beta-chain variant (8G4) Antibody

C3 is a key component of the complement system since classical and alternative activation pathways merge at the C3 activation step when C3 is split into C3a and C3b. The molecular mass of C3 is 185 kDa and it consists of alpha and beta chains (110 kDa and 75 kDa respectively) held together by disulfide bonds. This antibody is specific for an allotypic marker on human C3 (Leu instead of Pro in codon 314 of e, Xenopus/Amphibian,on 9), which occurs regularly in the beta-chain of C3F and occasionally in the beta-chain of C3S (F and S meaning fast and slow migration rate, respectively, on agarose gel electrophoresis). The antibody reacts with the 75-kDa beta-chain band of reduced C3 in immunoblotting , and reacts with the 20-kDa and 17-kDa beta-chain fragments produced by cyanogen bromide cleavage.

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SPECIFICATIONS

Catalog Number

250286

Size

0.1 mg

Applications

WB

Reactivities

Hum

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

C3 isolated from human plasma

Isotype

Mouse IgG2a/k

Accession

P01024

Clonality

8G4

Additional Info

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3; C3a anaphylato, Xenopus/Amphibian,in; Complement C3b alpha chain; Complement C3c alpha chain fragment 1; Complement C3dg fragment; C3d fragment; C3g fragment; C3f fragment; C3c alpha chain fragment 2

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