Reactivities: | Human |
Presku: | AAP69451 |
Size: | 100ug |
Weight: | 19kDa |
Gene: | 199990 |
Format: | Lyophilized powder |
Target: | C1orf86 is a component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. It promotes translesion synthesis via interaction with REV1. |
Alternative names: | FP7162 |