Binds with equal efficiency (Kd > 1 x 108 M) to the human free C-peptide and C-peptide region in proinsulin molecules. No cross-reactivity with human, bovine, porcine and mouse/rat insulin. Identified antigenic determinants are in the three-dimensional structure generated by N- and C- terminal regions of C-peptide separated by beta-turn at position 47-50 of proinsulin. Can be used for competitive ELISA/RIA detection of C-peptide in human serum after immunospecific removal of proinsulin; for construction of a sensitive two-site sandwich EIA/RIA immunosorbent assay for the measurement of total human proinsulin (including proinsulin convertion intermediates) in serum.
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