BUY TaiCatoxin

TaiCatoxin. Specific and Reversible Blocker of High Voltage Activated Ca²⁺�Channels.
TaiCatoxin is isolated from�Oxyuranus s.scutellatus�snake venom, by modification of the procedure of Possani and purified to homogeneity.

Taicatoxin was originally shown to be a specific and reversible blocker of high voltage activated Ca²⁺�channels in guinea pig and rat ventricular myocytes (probably Ca_v1.2). The IC₅₀�is voltage dependent decreasing from 500 nM at holding potential =-80 mV to 10 nM at holding potential = -30mV, indicating preference of block of the inactivated state of the channels.
However, another report shows that 50 nM Taicatoxin completely blocked SK_ca�apamin-sensitive channel.in chromaffin cells. Electrophysiological recordings were used to monitor Ca²⁺�currents or action potential parameters from isolated myocytes and from chromaffin cells.
In addition, TaiCatoxin was used to displace�¹²⁵I-Apamin binding in rat brain synaptosomes.