BUY omega-Agatoxin IVA

omega-Agatoxin IVA. A Blocker of P/Q-Type�Cav�Channels
Native�omega- Agatoxin IVA�was originally isolated from�Agelenopsis aperta�spider venom, and was shown to be a selective blocker of Cav2.1 (P/Q type) channels. However, the sensitivity depends on the auxiliary�beta�subunit isoform�and on the splice variant. Therefore, the effective concentration�varies between systems. In accordance, the toxin blocks presynaptic Ca²⁺�currents and synaptic transmission in a variety of synapses.

omega-Agatoxin IVA is widely used in electrophysiological measurements of cloned and native channels. It is used to assess the role of Cav2.1 channels in synaptic transmission. In addition it was used to map the spatial distribution of Cav2.1 channels in mouse cerebellar and hippocampal brain slices.
Ion Channel Modulators; Voltage - Gated Ca²⁺�Channel Blockers.