BUY Nicardipine HCI

Nicardipine HCl. A Potent Dihydropyridine Blocker of�Ca²⁺ Channels.
L-type (Ca_v1), voltage-gated Ca²⁺ channels are plasma membrane protein complexes which allow the passage of Ca²⁺ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases. Dihydropyridines (DHP) are molecules that act as allosteric modulators of L-type channels and many are used in the clinic to treat hypertension.

Nicardipine HCl is a dihydropyridine that acts as L-type, voltage-gated Ca²⁺ channel blocker and is used in the clinic to treat hypertension. Nicardipine inhibits L- and T-type Ca_v channels with similar potency. In human coronary myocytes, nicardipine inhibited the Ca²⁺ currents with an IC₅₀ of ~2 μM, While in porcine coronary artery strips 2 nM nicardipine were effective in inhibiting the constrictive response to of this muscle to endothelin. Ion Channel Modulators; Voltage - Gated Ca²⁺ Channel Blockers.