BUY Guangxitoxin-1E

Guangxitoxin-1E. A Potent Gating Modifier of K\_v\2.1, K\_v\2.2 and K\_v\4.3 K⁺ Channels.
Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family.
Guangxitoxin-1E is a gating modifier of K\_v\2.1 (KCNB1, IC₅₀ of 1 nM), K\_v\2.2 (KCNB2, IC₅₀ of 3 nM) and K\_v\4.3 (KCND3, IC₅₀ of 50 nM) channels. In pancreatic betacells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations.
The physiological modulation of K\_v\2.1 channels during glucose-induced insulin secretion is MgATP-mediated. No significant effect was found on K\_v\1.2 (KCNA2), K\_v\1.3 (KCNA3), K\_v\1.5 (KCNA5), K\_v\3.2 (KCNC2), Ca_v1.2 (CACNA1C), Ca_v2.2 (CACNA1B), Na_v1.5 (SCN5A), Na_v1.7 (SCN9A) or Na_v1.8 (SCN10A) channels.
Ion Channel Modulators; K⁺ Channel Blockers