Fasciculin-I is a 61 amino acid peptidyl toxin with four disulfide bonds, isolated from the Eastern green mamba (Dendroaspis angusticeps) venom. Fasciculin-I belongs to the three finger toxin family, structurally similar to the short alpha-neurotoxins and cardiotoxins. Fasciculin-I was shown to be a selective, potent, and reversible blocker of the mammalian acetylcholinesterase (AChE) at picomolar concentrations. Injection of Fasciculin-I to mice causes severe generalized and long-lasting twitch (fasciculation) due to its ability to accumulate acetylcholine at the neuromuscular junction.
Alomone Labs is pleased to offer Fasciculin-I (#F-650), a natural native toxin purified to homogeneity from the venom of the Eastern green mamba Dendroaspis angusticeps.
Neurotoxins>Anticholinesterase Polypeptide Toxins.
Quick Search
Products 
