Dendrotoxin-I. A potent blocker of Kvv1.1 and Kv1.2 Channels. Dendrotoxin-I is isolated from Dendroaspis p.polylepis snake venom, by modification of the procedure of Schweitz and purified to homogeneity. Dendrotoxin-I blocks Kv1.2 and Kv1.1 channels (IC50=0.13 and 3.1 nM in oocytes respectively, with higher values for mammalian cells) as well as heteromultimeric channels containing these, with other Kv1 isoforms. Ion Channel Modulators> K+ Channel Blockers.
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