alpha-Conotoxin ImI.
A Potent and Selective Blocker of Mammalian alpha3/beta2 Neuronal nAChR Channels
alpha-Conotoxin ImI is a 12 amino acid peptidyl toxin isolated from Conus Imperialis venom, which blocks mammalian neuronal nAChRs located on postsynaptic membranes.
This toxin inhibits in a voltage independent manner mammalian neuronal nAChRs (alpha3/beta2 > alpha7 > alpha3/beta4) and has no effect on nAChRs composed of alpha2/beta2, alpha3/beta2, alpha4/beta2, alpha2/beta4, alpha3/beta4, or alpha4/beta4 subunits.
Ion Channel Modulators; Nicotinic Acetylcholine Receptor Channel Blockers
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