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Btrc (beta-transducin repeat containing protein ) Blocking Peptide (the C terminal of Btrc)(100ug)

Btrc (beta-transducin repeat containing protein ) Blocking Peptide (the C terminal of Btrc)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Btrc Antibody (ARP42160_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP42160
Size: 100ug
Weight: 69kDa
Gene: The peptide is characterized by mass spectroscopy
Format: Lyophilized powder
Target: Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alternative names: Beta-Trcp1; FWD1; Fbw1a; KIAA4123; Slimb; b-TrCP; beta-TrCP; mKIAA4123
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