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Btrc (beta-transducin repeat containing protein ) Blocking Peptide (the C terminal of Btrc)(100ug)

Btrc (beta-transducin repeat containing protein ) Blocking Peptide (the C terminal of Btrc)(100ug)

This is a synthetic peptide designed for use in combination with anti-Btrc Antibody (ARP42160_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Mouse

Format

Lyophilized powder

Presku

AAP42160

Target

Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.

Weight

69kDa

Gene Id

The peptide is characterized by mass spectroscopy

Alternative Names

Beta-Trcp1; FWD1; Fbw1a; KIAA4123; Slimb; b-TrCP; beta-TrCP; mKIAA4123

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