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Brilliant Violet 605(TM) anti-mouse CD279 (PD-1)

Brilliant Violet 605(TM) anti-mouse CD279 (PD-1)

Cat no: 135219

Supplier: BioLegend
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CD279, known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein and belongs to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T, B lymphocytes, and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It was reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Catalogue number: 135219
Reactivities: Mouse
Hosts: Rat
Applications: Flow Cytometry
Size: 125 microl
Clone: 29F.1A12
Gene: 18566
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.Brilliant Violet 605(TM) excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605(TM) is a trademark of Sirigen Group Ltd.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Antigen: PD-1 cDNA followed by PD-1-Ig fusion protein
Isotype: Rat IgG2a, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Programmed Death-1, PD1
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