Brilliant Violet 421(TM) anti-mouse CD279 (PD-1)

CD279, known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein and belongs to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T, B lymphocytes, and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It was reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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SPECIFICATIONS

Catalog Number

135217

Size

125 microl

Applications

FC

Hosts

Rat

Reactivities

Mouse

Clone

29F.1A12

Antigen

PD-1 cDNA followed by PD-1-Ig fusion protein

Gene Id

18566

Isotype

Rat IgG2a, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.Brilliant Violet 421(TM) excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421(TM) is a trademark of Sirigen Group Ltd.

Storage Temp

4 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

Programmed Death-1, PD1

Regulatory Status

RUO