BLM Antibody

BLM, a helicase protein from the RecQ subfamily,Porcinearticipates in DNA replication and repair with a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. BLM is part of the BRCA1-associated genome surveillance comple, Xenopus/Amphibian, (BASC), which contains BRCA1,Mouse,SH2,Mouse,SH6,Mouse,LH1, ATM, BLM,PorcineMS2 and the RAD50-MRE11-NBS1 protein comple, Xenopus/Amphibian,. Defects in BLM are the cause of bloom syndrome, characterized by growth deficiency, skin pigmentation disorders,Porcineredisposition to malignancy and chromosomal instability.