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BIRC5 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250560

BIRC5 Antibody

BIRC5 (Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor suvivin) is a component of the chromosomal passenger comple, Xenopus/Amphibian, (CPC), a key regulator of mitosis that functions at the centromere to ensure correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. With RAN, survivin forms a scaffold for mitotic spindle formation to deliver the RAN effector TP, Xenopus/Amphibian,2 to microtubules. Survivin plsys a role in neoplasia. It inhibits caspase-3 and caspase-7, blocking a default induction of apoptosis in G2/M phase. It is e, Xenopus/Amphibian,pressed in fetal kidney, liver, lung, brain, adenocarcinomas, lymphomas, renal cell carcinoma cell lines.

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SPECIFICATIONS

Catalog Number

250560

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Bov, Can, Prc

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BIRC5.

Isotype

Rabbit IgG

Accession

O15392

Additional Info

BIRC5; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor suvivin; Apoptosis inhibitor 4; Survivin variant; AP14; IAP4

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