Biotin anti-mouse CD357 (GITR)

GITR glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18,and AITR (in humans).It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Treg cells.The expression of GITR on T cells can be upregulated upon activation.Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-kB activation, and abrogate the inhibitory function ofCD25+CD4+ T reg cells.In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

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SPECIFICATIONS

Catalog Number

126305

Size

50 microg

Applications

FC

Hosts

Rat

Reactivities

Mouse

Conjugates

Biotin

Clone

DTA-1

Antigen

mouse CD25+CD4+ T cells

Gene Id

21936

Isotype

Rat IgG2b, lambda

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C. Do not freeze.

Alternative Names

AITR, TNFRSF18

Regulatory Status

RUO