Biotin anti-mouse CD133

CD133 (also known as Prominin-1 or AC133) is a 120 kD pentaspan glycoprotein with 5 transmembrane domains which localize to cellular protrusions. CD133 was initially described as a surface antigen specific for human hematopoietic stem cells and as a marker for murine neuroepithelial cells and some embryonic epithelia. Later on, CD133 was found on other stem cells including endothelial progenitor cells, glioblastomas, neuronal, and glial stem cells. In addition to hematopoietic stem cells, CD133 was found on cancer cells, such as some leukemia cells and brain tumor cells. It also has been detected at low levels in the kidney, pancreas, placenta, and fetal liver tissue. Although the biological function of CD133 is not conclusive, CD133 has been extensively used as a stem cell marker for normal and cancerous tissues.

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SPECIFICATIONS

Catalog Number

141205

Size

25 microg

Applications

FC

Hosts

Rat

Reactivities

Mouse

Conjugates

Biotin

Clone

315-2C11

Antigen

CD133-expressing-GFP-RBL2H3 plus CFA as adjuvant.

Gene Id

19126

Isotype

Rat IgG2a, lambda

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

Prominin-1, AC133

Regulatory Status

RUO