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Biotin anti-mouse CD120b (TNF R Type II/p75)

Biotin anti-mouse CD120b (TNF R Type II/p75)

Cat no: 113403

Supplier: BioLegend
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CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-alpha and LT-alpha (also known as TNF-beta). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-alpha or LT-alpha trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.
Catalogue number: 113403
Reactivities: Mouse
Hosts: Hamster
Applications: Flow Cytometry
Conjugates: Biotin
Size: 50 microg
Clone: TR75-89
Gene: 21938
Dilutions: Each lot of this antibody is quality control tested by ELISA and/or immunofluorescent staining with flow cytometric analysis. For ELISA detection applications, a concentration range of 0.125-0.5 microg/ml is recommended. To obtain a linear standard curve, serial dilutions of TNF R Type II/p75 recombinant protein ranging from 250 to 4 pg/ml are recommended for each ELISA plate. For immunofluorescent staining, the suggested use of this reagent is ? 0.5 microg per 106 cells in 100 microl volume or 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: The antibody solution should be stored undiluted at 4C. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: E. coli -expressed mouse Type II TNFR
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TNFRII, TNFR type II, p75, TNFR80, TNFRSF1B
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