Biotin anti-human CD254 (TRANCE, RANKL)

Human RANKL (receptor activator of NF-kB ligand), also known as TRANCE (TNF-related activation-induced cytokine receptor) and OPGL (Osteoprotegerin ligand), and CD254, is a type II transmembrane protein in theTNF superfamily. It has two forms - a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. TRANCE is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of T cell and dendritic cell interactions. RANKL plays an important role in osteoclast differentiation and bone resorption. TRANCE activates JNK and NF-kappaB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.

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SPECIFICATIONS

Catalog Number

347506

Size

100 microg

Applications

FC

Hosts

Mouse

Reactivities

Hum

Conjugates

Biotin

Clone

MIH24

Antigen

RANKL-transfected L cells

Gene Id

8600

Isotype

Mouse IgG2b, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

TNF-related activation-induced cytokine receptor (TRANCE), CD254, RANK-L, OPGL, SOFA, TNFSF-11

Regulatory Status

RUO