Biotin anti-human CD126 (IL-6Ralpha)

CD126 is an 80 kD IL-6 receptor alpha chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor beta chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The beta chain (gp130, CD130) does not bind IL-6 by itself but associates with the alpha-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.

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SPECIFICATIONS

Catalog Number

352808

Size

100 microg

Applications

FC

Hosts

Mouse

Reactivities

Hum

Conjugates

Biotin

Clone

UV4

Antigen

Human myeloma cell line U266

Gene Id

3570

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?1.0 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

IL-6Ra, IL-6R1, gp80, IL-6 receptor alpha

Regulatory Status

RUO