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Bfl-1 Antibody (OAPB00432)

Bfl-1 Antibody (OAPB00432)

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumors, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. Presumably due to post-translational modifications, Bfl-1 is often observed at higher molecular weight in SDS-PAGE than its predicted molecular weight would suggest.

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SPECIFICATIONS

Size

0.1 mg

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB00432

Target

(NT) Bcl-2, apoptosis, cell death, Bax

Alternative Names

Bfl-1 (NT); Bcl-2-related protein A1; Hemopoietic-specific early response protein

SUPPLIER INFO

Aviva Systems Biology Incorporated

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