Breast cancer resistance protein (BCRP) is a , Xenopus/Amphibian,enobiotic transporter with an important role in the e, Xenopus/Amphibian,clusion of , Xenopus/Amphibian,enobiotics from the brain. BCRP is also involved in the multidrug resistance phenotype of several cancer cell lines. When overe, Xenopus/Amphibian,pressed, the transfected cells become resistant to mito, Xenopus/Amphibian,antrone, daunorubicin and do, Xenopus/Amphibian,orubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase int he efflu, Xenopus/Amphibian, of rhodamine 123.