Reactivities: | Human |
Presku: | AAP57508 |
Size: | 100ug |
Weight: | 25kDa |
Gene: | 605 |
Format: | Lyophilized powder |
Target: | This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. |
Alternative names: | BCL7 |